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Creative BioLabs Creative BioLabs Incはアメリカに本社を置き.イギリスとドイツにも拠点を持つ.
前身は2006に設立、2015年にfoundされました。創薬初期のステージで使用する技術としてPhage display,ハイブリドーマ作成などの実施が可能である.カスタムバイオテクノロジーと製薬サービスを提供する.創薬後期のステージで使用するヒト化技術,親和性成熟技術など,高度な分析技術を必要とするサービスも提供できる.を作製できる抗体は,研究用,診断用,治療用の提供が可能.cGMPによるモノクローナル抗体製造は1,000L規模で可能.100名の擁するContract Research Organization (CRO)です.。format変換, identification, affinity maturation, humanizationなどresearch段階での技術は高く、できることは沢山の説明はあります。
https://www.creative-biolabs.com/immuno-oncology/cell-culture-process-development.htm
Comprehensive service portfolio including antibody reformattingFab F(ab)’2 scFv VHH minibodies bispecific production epitope binning and mappingidentify the epitope elucidate the mechanism strengthen intellectual property humanizationvariety of methods and toolkits affinity maturationhigh-throughput phage library affinity measurement sequence liability identification immunogenicity predictionin vitro screening (Sensitive immunogenicity Assessment Technology; SIAT) in vivo screening cGMP manufacturing Development Culture media screening and adaptation Material preparation for different stages of projects, such as transient and pool material production Various bioreactors available Productivity and/or quality optimization 細胞培養プロセス開発クローン選択から培養条件の最適化 培養開発プラットフォーム 100名以上の専門スタッフ 1L~2,000L cGMP製造Wave Vi-cell YSI Cedex Bio HT Novaflex Bioprofile 400 BGA Terumo tubing welder Osmometer Steril tubing welder and sealer Integrity tester Media prep systems for lab & pilot plant Product Quality Optimization Aggregation control Charge variant control Glycosylation optimization Sialic acid content optimization ADCC/CDC activity optimization Late stage cell culture process development Technical transfer Commercial process development service Process characterization and validation IND-enabling cell culture activities Clone selection and process optimization Scale-up and toxicological material production Technical transfer for cGMP production for worldwide IND submissions Perfusion and concentrated fed-batch platform High viable cell density and viability For perfusion: long term steady-state operation and stable productivity and quality For concentrated fed-batch: quick adoption from fed-batch with high harvest product titer and improved quality From bench top scale-down model to cGMP anufacturing production GENE THERAPY DEVELOPMENT
Adeno-associated Virus Vector
様々なHost Cellを提供している YB2 / 0細胞株 : フコース含有率が低いラット骨髄腫細胞株
rcAAVの測定 委託で測定を受けてくれる。
Replication-component AAV testing
Replication-incompetent vector particles derived from AAV (adeno-associated virus) have been shown to mediate transfer and expression of heterologous genes (transgenes) into a variety of cells in vivo and in vitro . It has tremendous potential in both research and therapeutic applications.
https://www.creative-biogene.com/Services/Custom-Viral-Service/Replication-Competent-AAV-Testing.html 編集履歴
2019/09/26 はりきり(Mr)
2020/05/21 追記(詳細サービス)
2020/11/24 追記(rcAAV測定) 以上